希望我理解了您的提问角度。

搭配 be into sth = be interested in sth in an active way.

如 He is into surfing in a big way.  他彻底迷上了冲浪。I'm really into folk music. 我很热衷于民俗音乐。

搭配 be with sb = be able to understand what sb is talking about. 

如 Are you with me? 你明白我说的话么？ 

如 I'm afraid I'm not quite with you. 对不起我不太懂你的意思。