当然可以。with 有时=in spite of：
They love the team, with all its faults. 他们热爱这支球队，尽管它不尽如人意。
With all her faults he still liked her. 尽管她有那么多缺点，可他还是喜欢她。
With all her experience, she could not get a job. 尽管很有经验，她还是找不到工作
It's hard to believe that, with all her talent and hard work, she still didn't win the competition. 令人难以置信的是，尽管她有天资又肯苦练，但她却没有赢得这场比赛。
