clever at 与 clever with 并不同义。

1. clever at 搭配中的 clever 侧重指聪明或伶俐，多指一个人的理解力或天份比较好，通常译成“擅长……”（注意其中的介词不能换成in）。如：

Stuart is clever at arithmetic. 斯图尔特擅长于算术。

She was quite clever at drawing. 她擅长画画。

The Swiss are clever at making watches. 瑞士人擅长制表。

2. clever with 中的clever 侧重指熟练或灵巧，多指一个训练有素。如：

John is clever with his pen. 约翰的笔杆子不错。

Mary is clever with her fingers / hands. 玛丽的手很灵巧。