完全可以。例如：

whose 指物的转换：

We must repair the desks whose legs are broken.

We must repair the desks of which the legs are broken.

We must repair the desks the legs of which are broken.

whose 指人的转换：

I want to help the children whose parents died in the earthquake.

I want to help the children of whom the parents died in the earthquake.

I want to help the children the parents of whom died in the earthquake.