可以说:
What's wrong with you?
What's the matter with you?
那有没有what’s up with you?
就是说what’s up后面可不可以用with you?
恭喜你,蒙对了!
What's up with you?
三个表达意思差不多。最后一个表达的意思可能更多一些。不光指出了差错,还指发生了什么事情。
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“ What's up with sb ? ”是正确的用法。例如:
What's up? (= What is the matter?) 怎么回事?What's up with him? He looks furious.他怎么了?他看上去怒气冲冲的。(摘自《牛津高阶英汉双解词典》第9版p.2375)