She is tired of you telling her what should not to do.

上句后半部有错误。应为：

She is tired of you telling her what to do/what she should do.

you telling her what...=your telling her what...

这是动名词复合结构作介词of的宾语。动名词的逻辑主语通常由物主代词或名词所有格表示。但非正式语体用宾格代词或通格名词表示。尤其是当动名词做介词宾语的时候。