He is the only child in / of his family.
这句话中式用 in 还是用 of?
都可以,in侧重范围或地点,of侧重归属或所属。如:
She is the second child in the family. 她在家排行老二。《现代汉英综合大词典》
She is clearly the most articulate and self-possessed member of her family.显然,她是全家口才最好、最沉着冷静的人。《柯林斯高阶英汉双解词典》
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同意zengkkh老师解答