Many of us, in our desperate drive to be successful and care for our many responsibilities, feel terrible guilt.

【翻译】在渴望追求成功还要顾及承担许多责任的努力中，我们很多人会感到十分的内疚（有深深的负罪感）。

【分析】关键是这个介词短语的理解：in our desperate drive to be successful and care for our many responsibilities。

1. to be successful 和 care for our many responsibilities两个不定式作定语，修饰名词drive。

2. drive的意思是：欲望，冲动；努力，动力。desperate drive就是“极其渴望，极其努力”。

3. in our desperate drive to do sth. 类似于：in our attempt to do sth. 结构。例如：

We have already made considerable progress in our attempt to explore the universe about us.  在探索周围世界的努力中，我们已经取得了重大的进步。

4. to be successful是系表结构的不定式，同样可以作定语。例如：

His wish to be an actor has come true. 他想当演员的愿望实现了。

If he's lazy, he'll never fulfil his ambition to be a doctor.  如果他懒惰，他将永远也不会实现成为医生的抱负。